|
KMID : 0892920210300030256
|
|
Experimental Neurobiology
2021 Volume.30 No. 3 p.256 ~ p.261
|
|
|
High Levels of IL-8 and MCP-1 in Cerebrospinal Fluid of COVID-19 Patients with Cerebrovascular Disease
|
|
Guartazaca-Guerrero Sebastian
Rodriguez-Morales Jahir
Rizo-Tellez Salma A.
Solleiro-Villavicencio Helena
Hernandez-Valencia Aldo F.
Carrillo-Ruiz Jose Damian
Escobedo Galileo
Mendez-Garcia Lucia A.
|
|
|
Abstract
|
|
|
|
The coronavirus family has tropism for the Central Nervous System (CNS), however, there is no solid evidence demonstrating that the neurological effects of COVID-19 result from direct viral infection or systemic inflammation. The goals of this study were to examine the cytokine profile and the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) in cerebrospinal fluids (CSF) from two patients with cerebrovascular disease and COVID-19. Although the SARS-CoV-2 mRNA was not detected in CSF of both patients, we found abnormally high levels of numerous proinflammatory cytokines and chemokines, especially IL-8 and MCP-1. Since these chemokines mediate activation and recruitment of neutrophils, monocytes, and macrophages, it is feasible that cerebrovascular disease related-neuroinflammation found in both patients results from an exacerbated inflammatory response instead of SARS-CoV-2 direct invasion to CNS. These results suggest that neuroinflammation plays a key role in cerebrovascular disease and COVID-19.
|
|
|
KEYWORD
|
|
|
SARS-CoV-2, COVID-19, Cerebrospinal fluid, Cerebrovascular disease, IL-8, MCP-1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|